Pyloric stenosis - Neonatal Disorders

What is Pyloric Stenosis?

Pyloric stenosis is a condition in neonates characterized by the narrowing of the pylorus, which is the passage between the stomach and the small intestine. This narrowing impedes the passage of food from the stomach to the intestines, causing severe symptoms and complications if not treated promptly.

Signs and Symptoms

Neonates with pyloric stenosis typically present with projectile vomiting, which is forceful and can occur soon after feeding. The vomit may be free of bile, as the obstruction is above the bile ducts. Other symptoms include poor weight gain or weight loss, dehydration, and a palpable olive-shaped mass in the abdomen. The baby may also show signs of hunger and irritability due to the inability to retain food.

Causes and Risk Factors

The exact cause of pyloric stenosis is unknown, but it is believed to involve a combination of genetic and environmental factors. It tends to run in families and is more common in males than females. First-born male infants and those with a family history of the condition are at higher risk. Additionally, certain antibiotics, such as erythromycin, given in the neonatal period may increase the risk.

Diagnosis

Diagnosis of pyloric stenosis often involves a physical examination where a healthcare provider may feel the characteristic olive-shaped mass in the abdomen. Confirmatory diagnostic tests include ultrasound imaging, which can visualize the thickened pyloric muscle, and barium swallow, which shows the narrowed pylorus and delayed gastric emptying. Blood tests may also be conducted to check for electrolyte imbalances due to vomiting.

Treatment Options

The definitive treatment for pyloric stenosis is a surgical procedure called pyloromyotomy. This surgery involves splitting the thickened pyloric muscle to allow food to pass through to the intestines. It is typically performed laparoscopically and has a high success rate. Before surgery, it is crucial to address any dehydration and electrolyte imbalances through intravenous fluids.

Postoperative Care

After pyloromyotomy, most neonates recover quickly and can resume normal feeding within a few hours to days. Postoperative care includes monitoring for signs of infection, ensuring adequate hydration, and gradually reintroducing feedings. Parents are advised to watch for any recurrence of vomiting or other symptoms and to follow up with their healthcare provider as recommended.

Prognosis and Long-Term Outcomes

The prognosis for neonates with pyloric stenosis is excellent following timely surgical intervention. Most infants recover fully without long-term complications. However, it is essential to address the condition promptly to prevent severe dehydration, malnutrition, and other complications. Regular follow-up visits are important to monitor the infant's growth and development.

Prevention and Awareness

While there is no definitive way to prevent pyloric stenosis, awareness of the risk factors and early signs can lead to prompt diagnosis and treatment. Parents should seek medical attention if their newborn exhibits symptoms of projectile vomiting or other related concerns. Additionally, healthcare providers should be cautious when prescribing antibiotics known to increase the risk of this condition.

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