Platelet Transfusions - Neonatal Disorders

What Are Platelet Transfusions?

Platelet transfusions involve the administration of platelets to a neonate with low platelet counts, a condition known as thrombocytopenia. Platelets are essential for blood clotting and preventing excessive bleeding.

When Are Platelet Transfusions Needed in Neonates?

Platelet transfusions are commonly required in neonates with conditions such as neonatal alloimmune thrombocytopenia (NAIT), sepsis, intraventricular hemorrhage (IVH), and other hematological disorders. They are crucial when platelet counts drop below certain thresholds, typically

What Are the Risks Associated with Platelet Transfusions?

While life-saving, platelet transfusions carry risks such as infection, allergic reactions, and transfusion-related acute lung injury (TRALI). Additionally, there is a risk of alloimmunization, where the neonatal immune system develops antibodies against transfused platelets, complicating future transfusions.

How Are Platelets for Transfusion Obtained?

Platelets are typically collected from donor blood through a process called apheresis. In emergencies, platelets can also be pooled from multiple donors. It's essential that these platelets are matched to reduce the risk of alloimmunization and other complications.

What Are the Guidelines for Platelet Transfusions in Neonates?

Current guidelines suggest transfusions for neonates with platelet counts

Relevant Publications

Immature platelet counts in transfused platelet units given to neonates.

Issue Release: 2024

Preoperative consultation for determining the appropriate transfusion strategy.

Issue Release: 2024

Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes.

Issue Release: 2024

Myelodysplastic syndrome occurring after enfortumab vedotin treatment for metastatic urothelial carcinoma.

Issue Release: 2024

Relationship between thrombocytopenia and prognosis in children with septic shock: a retrospective cohort study.

Issue Release: 2024

Prophylactic versus restrictive platelet transfusion strategy in patients with haematological malignancies in the ICU setting, a propensity-score analysis.

Issue Release: 2024

Platelet transfusions in adult ICU patients with thrombocytopenia: A sub-study of the PLOT-ICU inception cohort study.

Issue Release: 2024

Demand forecasting for platelet usage: From univariate time series to multivariable models.

Issue Release: 2024

Anti-D Alloimmunization Following Rhesus-Incompatible Platelet Transfusion in a Myelodysplastic Syndrome Patient.

Issue Release: 2024

Reply: ABO nonidentical platelet transfusions and mortality.

Issue Release: 2024

Acute mixed-lineage leukemia treated with desensitization therapy prior to HLA-haploidentical transplantation with high donor-specific antibodies.

Issue Release: 2024

Rescue splenic artery embolization in an adult patient of sickle cell disease presented with acute splenic sequestration crisis.

Issue Release: 2024

A Comprehensive Study on the Hematological Progression of Sickle Cell Disease Patients with COVID-19 at the Center for Research and Control of Sickle Cell Disease, Bamako.

Issue Release: 2024

Therapeutic efficacy and safety of pathogen-reduced platelet components: Results of a meta-analysis of randomized controlled trials.

Issue Release: 2024

Construction of a predictive model for blood transfusion in patients undergoing total hip arthroplasty and identification of clinical heterogeneity.

Issue Release: 2024

Why might cord blood be a better source of platelets for transfusion to neonates?

Issue Release: 2024

Differences between Japanese new criteria and pregnancy-specific modified ISTH DIC scores for obstetrical DIC diagnosis.

Issue Release: 2024

Standardisation of Definition and Management for Bleeding Disorder of Unknown Cause: Communication from the SSC of the ISTH.

Issue Release: 2024

Avatrombopag for the salvage treatment of platelet transfusion refractoriness.

Issue Release: 2024

Anesthetic managements, morbidities and mortalities in retroperitoneal sarcoma patients experiencing perioperative massive blood transfusion.

Issue Release: 2024

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